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ea0037gp.11.07 | Calcium, Vitamin D and Bone (1) | ECE2015

Tainted vitamin D responses under methyl donor deficiency of the pre-osteoblast cells are caused by a decreased VDR expression and a disruption of PGC-1a: VDR co-regulators complex

Feigerlova Eva , Ewu Essi , Battaglia Shyuefang , Leininger Brigitte , Weryha Georges , Gueant Jean-Louis

Folate and cobalamin are methyl donors (MD) needed for synthesis of methionine, precursor of S-adenosylmethionine (SAM), the substrate of methylation in epigenetic, and epigenomic pathways. The MD deficiency (MDD) leads to a decrease in SAM/SAH ratio and hyperhomocysteinemia, which has been related to osteoporosis in humans and disruption of development of epiphyseal cartilage in rat. However, the underlying molecular mechanisms remain elusive.M...

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Tainted vitamin D responses under methyl donor deficiency of the pre-osteoblast cells are caused by a decreased VDR expression and a disruption of PGC-1a: VDR co-regulators complex

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